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Asian-Oceanian Journal of Pediatrics and Child Health Volume Three December 2004 Number Two NEONATAL LUPUS SYNDROME IN CHINESE BABIES
Authors: Reann Wai-Po Chu, MBChB, FHKAM(Paediatrics) Ngai-Shan Kwong, MBBS (HK), FHKAM(Paediatrics) Sik-Nin Wong, MBBS (HK), FHKAM (Paediatrics) Department of Paediatrics & Adolescent Medicine, Tuen Mun Hospital, Hong Kong
Address for correspondence: Dr Sik-Nin Wong Department of Paediatrics & Adolescent Medicine Tuen Mun Hospital, Tsing Chung Koon Road Tuen Mun, Hong Kong Email: snwong@hkucc.hku.hk
Abstract Systemic lupus erythematosus and Sjogren’s syndrome are common diseases in the Chinese community. However the true incidence and clinical manifestations of neonatal lupus syndrome (NLS) born to Chinese mothers with SLE or SS are not well described in the literature. We report our experience of managing four Chinese babies with NLS. Three mothers had SLE. One mother was asymptomatic though her mother and sister had SLE. The four babies were born at full term but relatively small (2.21 – 2.9 kg). All mothers and babies had positive anti-SSA/Ro and/or anti SSB/La antibodies. Only one baby had congenital complete heart block, and 2 patients had typical skin rash of NLS. Instead liver manifestations (as hepatomegaly, cholestasis, raised liver enzymes) were common (75%), as were cytopenias (75%). Manifestations may occur beyond the neonatal period. A larger prospective study is required to confirm these preliminary observations. Keywords : Neonatal lupus syndrome, Chinese, Complete heart block, Neonatal hepatitis |
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Latest Journal Volume Three December 2004 Number Two
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Updated July 2006 |
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